Changes in Ca2+ Removal Can Mask the Effects of Geometry During IP3R Mediated Ca2+ Signals
نویسندگان
چکیده
منابع مشابه
Observable effects of Ca2+ buffers on local Ca2+ signals.
Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have provided new information on Ca(2+) release from clustered IP(3)Rs. In the present paper, we use the mod...
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Ca(2+) is the most important second messenger controlling a variety of intracellular processes by oscillations of the cytosolic Ca(2+) concentration. These oscillations occur by Ca(2+) release from the endoplasmic reticulum (ER) into the cytosol through channels and the re-uptake of Ca(2+) into the ER by pumps. A common channel type present in many cell types is the inositol trisphosphate recep...
متن کاملControl of protein translation by IP3R-mediated Ca2+ release in Drosophila neuroendocrine cells
The inositol 1,4,5-trisphosphate receptor (IP3R) is one of two Ca2+ channels that gates Ca2+ release from ER-stores. The ligand IP3, generated upon specific G-protein coupled receptor activation, binds to IP3R to release Ca2+ into the cytosol. IP3R also mediates ER-store Ca2+ release into the mitochondria, under basal as well as stimulatory conditions; an activity that influences cellular bioen...
متن کاملIP3R, store-operated Ca2+ entry and neuronal Ca2+ homoeostasis in Drosophila.
The IP3R (inositol 1,4,5-trisphosphate receptor) releases Ca2+ from the ER (endoplasmic reticulum) store upon binding to its ligand InsP3, which is thought to be generated by activation of certain membrane-bound G-protein-coupled receptors in Drosophila. Depletion of Ca2+ in the ER store also activates SOCE (store-operated Ca2+ entry) from the extracellular milieu across the plasma membrane, le...
متن کاملTermination of Ca2+ Release for Clustered IP3R Channels
In many cell types, release of calcium ions is controlled by inositol 1,4,5-trisphosphate (IP₃) receptor channels. Elevations in Ca²⁺ concentration after intracellular release through IP₃ receptors (IP₃R) can either propagate in the form of waves spreading through the entire cell or produce spatially localized puffs. The appearance of waves and puffs is thought to implicate random initial openi...
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ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2019
ISSN: 1664-042X
DOI: 10.3389/fphys.2019.00964